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Diagnostic Testing

When considering radiologic testing with contrast agents in patients with CKD it is important to keep in mind the risks associated with each contrast agent. Radiological tests with iodinated contrast agents are known to accelerate renal function loss in patients with CKD and increase the risk of ESRD. The risk of contrast should be considered with the benefits of the information obtained from the diagnostic test. Similarly, magnetic resonance (MR) scanning with gadolinium has been reported to increase the risk of adverse events in patients with kidney disease and a consideration of the risks and benefits should be taken in account before ordering such a test.

Solomon RJ, Natarajan MK, Doucet S,et al; Investigators of the CARE Study Cardiac Angiography in Renally Impaired Patients (CARE) study: a randomized double-blind trial of contrast-induced nephropathy in patients with CKD. Circulation. 2007 Jun 26;115(25):3189-96.

Yerram P, Saab G, Karuparthi PR, et al. Nephrogenic systemic fibrosis: a mysterious disease in patients with renal failure--role of gadolinium-based contrast media in causation and the beneficial effect of intravenous sodium thiosulfate. Clin J Am Soc Nephrol. 2007 Mar;2(2):258-63.

Last Updated - May 08 2017 15:25:51.

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